Mechanism of Action

Antizol is a Potent Inhibitor of Alcohol Dehydrogenase

• Antizol is a competitive inhibitor of alcohol dehydrogenase, the enzyme responsible for catalyzing the initial steps in the metabolism of ethylene glycol and methanol to their respective toxic metabolites. ¹²

  Competitive Inhibition of Alcohol Dehydrogenase by Antizol

• In vitro studies indicate that the affinity of fomepizole for alcohol dehydrogenase (ADH) is approximately 8,000-fold greater than ethanol. ¹⁵
• If the patient is hemodynamically stable and without renal compromise, Antizol has a recommended 12-hour dosing schedule, which assures ADH inhibition without the need for monitoring serum fomepizole concentrations. ¹²
• The dosing frequency of Antizol must be increased during hemodialysis. ¹²

Antizol treatment may be initiated immediately upon suspicion or documentation of ethylene glycol or methanol poisoning. This can be determined by many factors such as patient history, clinical signs, symptoms and laboratory findings, or measurement of a toxic plasma ethylene glycol or methanol concentration. In addition to antidotal treatment with Antizol, hemodialysis should be considered in some situations. A regional poison control center can provide current treatment recommendations.