Antizol: The antidote of choice for the treatment of ethylene glycol and methanol poisoning ¹

• Antizol is the only antidote FDA-approved for the treatment of ethylene glycol and methanol poisoning. ¹²
• Antizol is recommended by some experts as first line treatment of ethylene glycol and methanol poisoning. ¹³
• Antizol is recommended for the treatment of ethylene glycol and methanol poisoning by the American Academy of Clinical Toxicology. ^{4, 9}
• Antizol may eliminate the need for hemodialysis in select cases of ethylene glycol poisoning. ^{18, 20}
• Antizol may be more cost-effective than older therapies in many situations. ^{14, 23}
• Jazz Pharmaceuticals’ has a simple policy for the return of unused vials that expire on the pharmacy shelf.
• Antizol may be safely administered while awaiting laboratory confirmation of suspected ethylene glycol and methanol poisonings. ¹²
• Antizol has a simple dosing protocol based on body weight with straightforward administration: dilute and infuse. ¹²

Antizol should not be administered to patients with a documented serious hypersensitivity reaction to Antizol or other pyrazoles. The most frequent adverse reactions to Antizol are headache (14%), nausea (11%), dizziness, increased drowsiness and bad taste/metallic taste (6% each). ¹²

Ethylene glycol plasma and urine concentrations, as well as the presence of urinary oxalate crystals in ethylene glycol poisoning and methanol plasma concentrations in methanol poisoning, should be monitored throughout treatment. Minor allergic reactions (rash and eosinophilia) have been reported. ¹²

In the event of a real or suspected ethylene glycol or methanol poisoning, contact a Regional Poison Control Center for current treatment recommendations or consult with a medical toxicologist, as needed (Nationwide:1-800-222-1222).