Efficacy of Antizol in ethylene glycol poisoning Efficacy of Antizol in for methanol poisoning

Efficacy and Safety

The efficacy of Antizol as an antidote for toxic ethylene glycol and methanol ingestion is well established and currently it is the most widely-used antidote for the treatment of these poisonings. ¹ Several publications have described the efficacy of Antizol for the treatment of ethylene glycol and methanol poisoning. ⁴^, ⁵^, ⁹^, ¹⁶^, ¹⁷^, ¹⁸^, ¹⁹

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Antizol Safety Information

Antizol should not be given undiluted or by bolus injection. Venous irritation and phlebosclerosis were noted in two of six normal volunteers given bolus injections (over 5 minutes) of Antizol at a concentration of 25 mg/ml.
Antizol may be safely administered while awaiting laboratory confirmation of suspected ethylene glycol and methanol poisonings.
The most frequent adverse events reported as drug-related or unknown relationship to study drug in the 78 patients and 63 normal volunteers who received Antizol® (fomepizole) Injection were headache (14%), nausea (11%), and dizziness, increased drowsiness, and bad taste/metallic taste (6% each). All other adverse events in this population were reported in approximately 3% or fewer of those receiving Antizol.
Minor allergic reactions (mild rash, eosinophilia) have been reported in a few patients receiving Antizol (see ADVERSE REACTIONS section of the package insert). Therefore, patients should be monitored for signs of allergic reactions.
Antizol treatment is well-tolerated during prolonged administration.
Antizol does not worsen central nervous system depression or cause hypoglycemia.
The use of Antizol does not require monitoring plasma fomepizole concentrations and in select cases of ethylene glycol poisoning, Antizol may eliminate the need for hemodialysis.
The only contraindication to the use of Antizol is a known hypersensitivity to fomepizole or other pyrazoles.
Antizol is approved for the treatment of real or suspected ethylene glycol and methanol poisoning. Please see the full prescribing information for a complete discussion of INDICATIONS and USAGE, CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS, and OVERDOSAGE.

Antizol treatment may be initiated immediately upon suspicion or documentation of ethylene glycol or methanol poisoning based on patient history, clinical signs, symptoms and laboratory findings or measurement of a toxic plasma ethylene glycol or methanol concentration. In addition to antidotal treatment with Antizol, hemodialysis should be considered in some situations. A regional poison control center can provide current treatment recommendations.