Efficacy in Methanol Poisoning

Methanol

Brent J, et al. New Engl J Med 2001; 344:424.

This prospective, multicenter clinical trial examined the efficacy of fomepizole for the treatment of methanol poisoning in 11 consecutive patients with serum methanol concentrations > 20 mg/dL, demonstrating that fomepizole is safe and effective for the treatment of methanol poisoning.

Mégarbane B, et al. Intensive Care Med 2001; 7:1370.

The results of this retrospective study of 14 patients treated with fomepizole led these investigators to conclude that hemodialysis may be unnecessary in methanol-poisoned patients presenting without visual impairment or severe acidosis.

Barceloux DG, et al. J Toxicol Clin Toxicol 2002; 40:415.

In this extensive review of methanol poisoning and its treatment, the authors provided the indications for antidotal treatment, suggesting that fomepizole is the preferred antidote for methanol poisoning.

Antizol is Effective for the Treatment of Methanol Poisoning

Change In Plasma Formate Concentrations Following Antizol Administration

In a series of 8 methanol-poisoned patients, the administration of Antizol effectively inhibited further metabolism of methanol to formate. The top figure demonstrates the change in methanol and formate concentrations in 3 patients who were treated with Antizol alone. The bottom figure demonstrates the change in methanol and formate concentrations in 5 patients who were treated with hemodialysis. Initial values were obtained within an hour of Antizol administration (in both figures, solid lines indicate mean values). ⁵

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